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(More customer reviews)Long story short, I think this form of B12 along with Hydroxy B12 are the best as they give me the benefits of B12 but without shattering my sleep/wake cycle like taking even a small amount of MB12 does - I can't take MB12 at all. It makes me ill from lack of sleep. Some do very well with MB12 though but I did just want to put this warning about it out there anyway for anyone else that it doesn't agree with!
As this product is quite high dosage I take only a quarter tablet a week. It is one of the best tasting sublinguals as well, incidentally.This is from a piece I write on B vitamins recently:
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Vitamin B12 guards against stroke, lowers homocysteine levels, improves general wellbeing and sleep, improves allergies and asthma, treats peripheral neuropathy, is required by the body to make myelin, is needed for healthy nerve function, improves CNS function and cognitive function, can help normalise low blood pressure (and low blood pressure or faintness on standing), improves digestion, plays an important role in forming red blood cells and supports detoxification processes. Doses over 1mg should also be taken with at least 1 mg of folate. There are several different forms of vitamin B12.
Hydroxycobalamin: This form of B12 is longer acting and raises blood levels of B12 higher. The therapeutic dosage of vitamin B12 as hydroxycobalamin is usually 1 - 5 mg, or sometimes 10 mg at the beginning of treatment. May reset the sleep/wake cycle too severely at higher doses, requiring that the dose be lowered.
Dibencozide: Extra B12 as dibencozide may also be useful. Dibencozide is a primary coenzyme form of vitamin B12. It is required for processing branch chain amino acids through the Kreb's cycle for sustained energy production and is involved in methionine and choline metabolism, red blood cell formation, and maintaining the integrity of myelin (a fatty insulation that covers some nerves), as well as promoting normal folic acid metabolism. Sublingual dosage is 1 mg or more daily.
Methylcobalamin: Methylcobalamin is an active coenzyme form of vitamin B12, is essential for cell growth and replication. It is more concentrated than other forms of B12 in the cerebral spinal fluid where it can be used by the central nervous system. It donates methyl groups to the myelin sheath that insulates certain nerve fibers. It also plays a role in maintaining a healthy sleep/wake cycle, as well as normal nerve function.
Large doses may work too well to reset the sleep/wake cycle. They may reduce total sleep time and promote early waking. Thus, this form of B12 should only be tried at very low doses to start with if you are very ill and have lots of sleep issues (as B12 takes months to leave the system) and may only be able to be tolerated in very low doses longer term. As with activated folate, a good starting dose may be just 1/10th of a (1 mg) tablet a day. Where MB12 is well tolerated, dosage is 1 - 5 mg daily. 200 - 500 mcg daily (plus some extra B12 in another form) may be a better dose if problems caused by MB12 with the sleep/wake cycle are severe.
Another way to get some of the benefits of methylcobalamin B12 is to take hydroxycobalamin. Despite the fact it is not an activated form of vitamin B12, this form of B12 is one of the most beneficial as it is a potent detoxifier. A small part of hydroxycobalamin supplements taken will be turned into methylcobalamin by the body, and so hydroxycobalamin also has a positive but more subtle effect on the sleep/wake cycle that is less likely to cause relapse in the very ill.
Cyanocobalamin: This form is okay to take if it is included in small amounts in multivitamins or B complex products but should never be the form of B12 chosen when purchasing a stand-alone B12 supplement. At high doses hydroxycobalamin, methylcobalamin or dibencozide rather than cyanocobalamin must be used to avoid the toxicity of the cyanide in the later. Vitamin B12 may be injected or given by IV, or taken equally effectively via sublingual tablets. There is no need for injections if you can find a good sublingual product like this one.
Whichever form you take, it is essential to start at a low dose and work up slowly as B12 (especially hydroxocobalamin) helps with detoxification. Going slow is also very important as if enough is taken to too-severely affect the sleep/wake cycle this can then take several months to wear off, as B12 is stored in the muscles and in organs. B12 is well tolerated by most patients and B12 is extraordinarily safe even in high amounts.
The effects from B12 may seem to wear off after a long period of treatment, so some doctors recommend stopping B12 treatment for a month and then restarting it to get around this problem.
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This product is very good and probably best taken with Source Naturals coenzymated sublingual B complex product. B vitamins should never be taken in isolation.
Jodi Bassett, The Hummingbirds' Foundation for Myalgic Encepahlomyelitis
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