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(More customer reviews)I find that I really need B vitamins in their coenzymated forms. I got a real boost from taking this product that I did not get from taking larger amounts of oral B vitamins in a non-coenzymated form.
I take this product with some extra coenzymated B complex and some HB12. I take higher amounts of B vitamins - and especially B1 - as per the Klenner neurological disease treatment protocol. (I'm slowly improving form a severe neurological and cardiovascular disease called M.E.)
I also take soem extra B1 as benfotiamine.
This is from a short paper I recently wrote on sublingual coenzymated B vitamins:
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In order for B vitamins to be utilized by the body, they must first be converted into their active coenzyme forms by the liver. This conversion takes time and requires metabolic energy, which may be in short supply in some diseases.
For most healthy, young individuals, this conversion of synthetic B vitamins into coenzymated vitamins does not present a problem. However, in older, ill or nutritionally-deficient people or certain individuals with a particular biochemical deficiency, the conversion may be problematic. When this occurs, supplementing with non-coenzymated B vitamins may have little effect.
Our livers are working harder than ever before with the hugely increased amount of toxins they have to process and neutralise in the 21st century. This is one reason why the liver's ability to coenzymate vitamins into their active forms can be greatly impaired (which can affect our entire biochemistry). Some people also have particular problems converting vitamin B6 or folate to their active forms. For these people, only the coenzymated form of these vitamins will be able to be used by the body.
Where there are problems converting one or more of the B vitamins into their active coenzyme forms by the liver coenzymated sublingual B vitamins will be by far the best choice of B supplement. In studies with chronic alcoholics (a group at high risk of poor liver function) large doses of B vitamins were given by IV. Normally, the administration of these IVs would raise the body's coenzyme levels, but in the case of liver-impaired alcoholics, it did not. This shows that a compromised liver may not be able to Coenzymate vitamins optimally. Thus when a person cannot convert B vitamins properly, even injections or IVs of non-coenzymated vitamins will have little or no effect. So for some people, the optimum way to take in B vitamins is not by IV but through coenzymated products.
Coenzyme forms of vitamins are biologically identical to those used by the body, making them highly bioavailable, especially when they are also in a sublingual form. Sublingual tablets are absorbed rapidly into the highly capillarised tissues found in the cheeks and under the tongue and enter the bloodstream intact, without the risk of being degraded or diminished by the digestive system. Taking coenzymate and sublingual forms of B vitamins also conserves valuable metabolic energy and reduces the load on the (probably very overworked already) liver. Vitamins taken in this form will also be faster acting.
Smaller doses are needed when the coenzymate forms of vitamins are taken and when nutrients are taken sublingually. Coenzymated forms of vitamin B are up to five times more biologically active than other forms. One study using both sublingual and oral supplements (testosterone in this case) found that the absorption of the sublingual was twice that of the oral dose.
Taking 150 mg daily of a B vitamin complex product should bring noticeable effects and benefits within 2 - 4 weeks. It should improve wellbeing generally, improve concentration, improve mood and make you feel more able to cope with stress. You should really be able to feel a significant difference. If 150 mg of an oral B complex is taken for a month with little or no effect, a sublingual coenzymated B complex product should be trialled. Try 2 or 3 sublingual lozenges daily (depending on the brand). A short trial of this nature is a very good idea if you are seriously ill.
The downside of sublingual vitamins is the higher cost and taking in so much mannitol or sorbitol and other undesirable substances.
Source naturals makes a good quality coenzymated B complex, plus sells each of the coenzymated B vitamins individually as well. Their product is the best I have found.
Avoid products which contain a mixture of standard and coenzymated B vitamins and which do not disclose how much of each type is contained in the product. (You may be paying a premium price for a product that contains only 1% or less of the more expensive coenzymated form of the vitamin. If the percentages are not listed, assume the coenzymated vitamin percentage in the product is very low!)
The B vitamins have also recently become available in a liposomal delivery system. A liposomal B complex product is now available from Livon Labs and the product is called AGE blocker. The downside here is that the B vitamins are not available individually and so it may not be possible to get enough B1 or other more desired B vitamins without getting more than needed of the other B vitamins as well as the other nutrients included in the product. Liposomal delivery systems make nutrients very bio-available and so smaller amounts are needed than with oral forms. -----
I wish this came in orange flavour. It doesn't taste bad when you have food afterwards as with this pepperminty one. The minty flavour isn't strong but I still dislike it.
Jodi Bassett, The Hummingbirds' Foundation for Myalgic Encepahlomyelitis
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